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ICONCL2375 Nilotinib(AMN 107) (641571-10-0)
 
 
Catalog No.: CL2375
CAS No.: 641571-10-0
Synonym: AMN-107,Tasigna
Chemical Name:

4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide.

Molecular Formula:

C28H22F3N7O

Molecular Weight: 529.52
 
Technical Data:
Appearance: White or almost white powder
Solubility: Soluble in DMSO
Purity: >99%
Storage: Store at +4°C
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Nilotinib(AMN 107):

Size

Price

Stock

500 mg 

USD 218

In stock 

1 g 

USD 326

In stock 

2 g USD   588 In stock

5 g 

USD 886

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

A highly selective inhibitor of Bcr-Abl, the definitive cause of Ph+ CML, and its mutations.

 
References:

1. Gallipoli P  et al. JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood : (2014).

2. Zhang H  et al. Inhibition of MDM2 by nilotinib contributes to cytotoxicity in both Philadelphia-positive and negative acute lymphoblastic leukemia. PLoS One 9:e100960 (2014).

 
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