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ICONC13349 AZD1152-HQPA(Barasertib) (722544-51-6)
 
 
Catalog No.: C13349
CAS No.: 722544-51-6
Synonym: Barasertib; AZD1152; AZD 1152
Chemical Name:

2-(5-((7-3-(Ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-yl)amino)-1H-pyrazol-3-yl)-N-(3-fluorophenyl)acetamide
Molecular Formula:

C26H30FN7O3
Molecular Weight: 507.56
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of AZD1152-HQPA(Barasertib):

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities
 
Biological Activity:

AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1.369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases. The dihydrogen phosphate prodrug, AZD 1152 (Barasertib), is converted rapidly to active AZD1152-HQPA in plasma.
 
References:
Oke, Adedayo; Pearce, Daniel; Wilkinson, Robert W.; AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo. Cancer Research (2009), 69(10), 4150-4158.
 
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