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ICONC13834 Lovastatin(Mevinolin) (75330-75-5)
 
 
Catalog No.: C13834
CAS No.: 75330-75-5
Synonym: Mevinolin
Chemical Name:

(2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a­-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4­-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl­-2-methyl butanoate
Molecular Formula:

C24H36O5
Molecular Weight: 404.54
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Lovastatin(Mevinolin):

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities
 
Biological Activity:

Lovastatin is a member of the drug class of statins, used in combination with diet, weight-loss, and exercise for lowering cholesterol (hypolipidemic agent) in those with hypercholesterolemia to reduce risk of cardiovascular disease. Lovastatin is a naturally occurring drug found in food such as oyster mushrooms and red yeast rice.
 
References:
  1. Gunde-Cimerman N, Cimerman A. (Mar 1995). "Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin.". Exp Mycol. 19 (1): 1–6.doi:10.1006/emyc.1995.1001. PMID 7614366.
  2. Liu J, Zhang J, Shi Y, Grimsgaard S, Alraek T, Fønnebø V (2006). "Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials". Chin Med 1: 4. doi:10.1186/1749-8546-1-4. PMC 1761143. PMID 17302963.
  3. "Lovastatin". The American Society of Health-System Pharmacists. Retrieved 3 April 2011.
  4.  Alarcón J, Aguila S, Arancibia-Avila P, Fuentes O, Zamorano-Ponce E, Hernández M (2003 Jan-Feb). "Production and purification of statins from Pleurotus ostreatus (Basidiomycetes) strains". Z Naturforsch C 58 (1–2): 62–4. PMID 12622228.
  5. Vederas JC, Moore RN, Bigam G, Chan KJ (1985). "Biosynthesis of the hypocholesterolemic agent mevinolin by Aspergillus terreus. Determination of the origin of carbon, hydrogen and oxygen by 13C NMR and mass spectrometry". J Am Chem Soc 107 (12): 3694–701. doi:10.1021/ja00298a046.
 
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