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C14336 Voglibose(A 71100) (83480-29-9)

Catalog No.:	C14336
CAS No.:	83480-29-9
Synonym:	A 71100
Chemical Name:	5-(1,3-Dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol
Molecular Formula:	C₁₀H₂₁NO₇
Molecular Weight:	267.13

Technical Data:

Appearance:
Solubility:	Soluble in DMSO and Water
Purity:	>98%
Storage:	Store at room temperature.
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Voglibose(A 71100):

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

Orally active α-glucosidase inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo.

References:

1. Jones RB et al. Effect of linagliptin, alone and in combination with voglibose or exendin-4, on glucose control in male ZDF rats. Eur J Pharmacol 729:59-66 (2014).

2. Mukherjee A & Sengupta S Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present in Azadirachta indica (neem) useful for the treatment of diabetes. J Enzyme Inhib Med Chem 28:900-10 (2013).

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