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HL1001 D-Bicuculline (485-49-4)

Catalog No.:	HL1001
CAS No.:	485-49-4
Synonym:	(+)-Bicuculline
Chemical Name:	[R-(R,S)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one
Molecular Formula:	C₂₀H₁₇NO₆
Molecular Weight:	367.36

Technical Data:

Appearance:	Pale yellow crystalline powder
Solubility:	Soluble in ethanol and DMSO
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of D-Bicuculline:

Size	Price	Stock
20 mg	USD 350	In stock
50 mg	USD 460	In stock
100 mg	USD 736	In stock

Biological Activity:

Antagonist of the GABAA receptor.
(+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABA_A receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.

References:

Bormann J The 'ABC' of GABA receptors. Trends Pharmacol Sci 21:16-9 (2000)

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