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Biological Activity:
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A-cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxid.
References:
Moussaïf M et al.Cyclosporin C is the main antifungal compound produced by Acremonium luzulae.Appl Environ Microbiol63:1739-43 (1997).
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