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CL2104 Agomelatine(S20098) (138112-76-2)

Catalog No.:	CL2104
CAS No.:	138112-76-2
Synonym:	S-20098,Valdoxan
Chemical Name:	N-(2-(7-Methoxynaphth-1-yl)ethyl)acetamide
Molecular Formula:	C₁₅H₁₇NO₂
Molecular Weight:	243.30

Technical Data:

Appearance:	White or almost white powder
Solubility:	Soluble in DMSO and Ethanol
Purity:	>99%
Storage:	Store at room temperature.
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Agomelatine(S20098):

Size	Price	Stock
100 mg	USD 220	In stock
200 mg	USD 316	In stock
500 mg	USD 416	In stock

Biological Activity:

Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways.Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant.

References:

Ladurelle N et al. Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Psychopharmacology (Berl) 221:493-509 (2012).

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