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Pharmacology

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Cardiovascular System

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Vitamin D series compounds

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CL1810A Plerixafor (110078-46-1)

Catalog No.:	CL1810A
CAS No.:	110078-46-1
Synonym:	JM 3100,AMD3100
Chemical Name:	1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane
Molecular Formula:	C₂₈H₅₄N₈
Molecular Weight:	502.78

Technical Data:

Appearance:	White powder
Solubility:	Freely Soluble in water ,in ethanol and in etherl
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Plerixafor:

Size	Price	Stock
50 mg	USD 236	In stock
100 mg	USD 366	In stock
250 mg	USD 426	In stock

Biological Activity:

A macrocyclic compound and potential fusion inhibitor. It is an antagonist (or perhaps more accurately a partial agonist) of the alpha-chemokine receptor CXCR4 & an allosteric agonist of CXCR7.

References:

1. Zabel BA, et al. J Immunol. 2009, 183(5), 3204-3211.

2. Fricker SP, et al. Biochem Pharmacol. 2006, 72(5), 588-596.

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