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C13249 ABT-737 (852808-04-9)

Catalog No.:	C13249
CAS No.:	852808-04-9
Synonym:	ABT737; ABT 737
Chemical Name:	4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Molecular Formula:	C₄₂H₄₅ClN₆O₅S₂
Molecular Weight:	813.43

Technical Data:

Appearance:	Yellow solid
Solubility:	Soluble in DMSO
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of ABT-737 :

Size	Price	Stock
10mg	USD	In Stock
50mg	USD	In Stock
100mg	USD	In Stock

Biological Activity:

A selective inhibitor of BCL-2, in small cell lung cancer.

References:

1. Yang MC et al. Bcl2L12 with a BH3-like domain in regulating apoptosis and TMZ-induced autophagy: A prospective combination of ABT-737 and TMZ for treating glioma. Int J Oncol : (2015).

2. Gu D et al. Inhibition of the MDM2 E3 Ligase induces apoptosis and autophagy in wild-type and mutant p53 models of multiple myeloma, and acts synergistically with ABT-737. PLoS One 9:e103015 (2014).

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