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C13781 Ivabradine hydrochloride (148849-67-6)

Catalog No.:	C13781
CAS No.:	148849-67-6
Synonym:	Ivabradine HCl
Chemical Name:	3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
Molecular Formula:	C₂₇H₃₆N₂O₅^.HCl
Molecular Weight:	505.05

Technical Data:

Appearance:
Solubility:	Soluble in Water
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Ivabradine hydrochloride:

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

Studies have shown that Ivabradine inhibits T cell migration and causes a decrease of chemokine-induced PI-3 kinase activity. Exposure of rabbit sinoatrial node cells to Ivabradine has been reported to cause a blockade of the hyperpolarization-activated I(f) current without resulting in a shift of the voltage range of the activation curve.

References:

1. Thollon, C., et al. 1994. Br. J. Pharmacol. 112: 37-42. PMID: 8032660
2. Bois, P., et al. 1996. Br. J. Pharmacol. 118: 1051-1057. PMID: 8799581
3. Ragueneau, I., et al. 1998. Clin. Pharmacol. Ther. 64: 192-203. PMID: 9728900
4. Borer, J.S., et al. 2003. Circulation. 107: 817-823. PMID: 12591750
5. Walcher, T., et al. 2010. Mediators Inflamm. 2010 : 751313. PMID: 21188276

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