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Biological Activity:
Glycoside-derivative of podophyllotoxin. Has cytostatic effect. Inhibits topoisomerase II. Induces apoptosis.A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.
References:
Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),