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C13927 Neratinib(HKI 272) (698387-09-6)

Catalog No.:	C13927
CAS No.:	698387-09-6
Synonym:	HKI-272; HKI272; HKI 272
Chemical Name:	(2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
Molecular Formula:	C30H29ClN6O3
Molecular Weight:	557.09

Technical Data:

Appearance:
Solubility:	Soluble in DMSO
Purity:	>98%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Neratinib(HKI 272):

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

An irreversible tyrosine kinase inhibitor with activity against HER2 and EGFR kinases; a therapeutic agent under investigation for the treatment breast cancer and other solid tumours.

References:

Rabindran SK, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res, 2004, 64(11), 3958-3965.

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