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ICONCL2190 Neratinib(HKI 272) (698387-09-6)
 
 
Catalog No.: CL2190
CAS No.: 698387-09-6
Synonym: HKI-272; HKI272; HKI 272
Chemical Name:
(2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
Molecular Formula: C30H29ClN6O3
Molecular Weight: 557.09
 
Technical Data:
Appearance: Pale yellow to white powder
Solubility: Soluble in DMSO
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Neratinib(HKI 272):

Size

Price

Stock

100 mg 

USD 126

In stock 

200 mg 

USD 206

In stock 

500 mg 

USD 336

In stock 

Contact us for competitive discounts on bulk quantities
 
Biological Activity:

An irreversible tyrosine kinase inhibitor with activity against HER2 and EGFR kinases; a therapeutic agent under investigation for the treatment breast cancer and other solid tumours.


 
References:
 Rabindran SK, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res, 2004, 64(11), 3958-3965.
 
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