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ICONC13933 Nilotinib hydrochloride Monohydrate (923288-90-8)
 
 
Catalog No.: C13933
CAS No.: 923288-90-8
Synonym: AMN-107; Tasigna; AMN107
Chemical Name:

Nilotinib hydrochloride Monohydrate

 
Molecular Formula: C28H22F3N7O·HCl·H2O
Molecular Weight: 583.99
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Nilotinib hydrochloride Monohydrate:

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities
 
Biological Activity:
Nilotinib is a inhibitor of BCR-ABL, IC50 < 30nM; for the treatment of chronic myelogenous leukemia.
 
References:

1. Liu Y, et al. Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib. J Hepatol. 2011 Sep;55(3):612-25. 
2. Weisberg E, et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell. 2005 Feb;7(2):129-41.
 
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