Buy Sofosbuvir(PSI-7977)|1190307-88-0|DNA damage|from supplier chembestbuy.com|Research only

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C14739 Sofosbuvir(PSI-7977) (1190307-88-0)

Catalog No.:	C14739
CAS No.:	1190307-88-0
Synonym:	PSI 7977;Sofosbuvir;GS-7977;PSI7977
Chemical Name:	N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;Isopropyl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate
Molecular Formula:	C₂₂H₂₉FN₃O₉P
Molecular Weight:	529.45

Technical Data:

Appearance:
Solubility:	Soluble in DMSO
Purity:	>98%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Sofosbuvir(PSI-7977):

Size	Price	Stock
10mg	USD	In Stock
25mg	USD	In Stock
50mg	USD	In Stock

Biological Activity:

PSI-7977 is an investigational nucleotide analog currently in Phase 2 for treatment of chronic HCV infection. PSI-7851 is a mixture of two similar molecules, PSI-7976 and PSI-7977, which exist in PSI-7851 as isomers of each other. Once inside a liver cell, both molecules are rapidly converted to the same active triphosphate. Given the ability to more easily manufacture PSI-7977, and potentially advantageous in vitro characteristics, PSI-7977 was selected for further clinical development. Antiviral agents.

References:

1. Murakami E, et al. J Biol Chem, 2010, 285(45), 34337-34347.

2. Sofia MJ, et al. J Med Chem, 2010, 53(19), 7202-7218.

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