Buy Decitabine(NSC127716)|2353-33-5|DNA damage|from supplier chembestbuy.com|Research only

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CL2368 Decitabine(NSC127716) (2353-33-5)

Catalog No.:	CL2368
CAS No.:	2353-33-5
Synonym:	2'-Deoxy-5-azacytidine, 5-Aza-2'-deoxycytidine;Dezocitidine
Chemical Name:	5-Aza-2'-deoxycytidine; 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
Molecular Formula:	C₈H₁₂N₄O₄
Molecular Weight:	228.21

Technical Data:

Appearance:	White to off white crystalline powder
Solubility:	Soluble in DMSO
Purity:	>99%
Storage:	Store at +4°C
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Decitabine(NSC127716):

Size	Price	Stock
500 mg	USD 186	In stock
1 g	USD 246	In stock
5 g	USD 656	In stock

Biological Activity:

Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.

References:

Shin DY et al. Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation. Int J Oncol 41:910-8 (2012).

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