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CL2197 Topotecan hydrochloride (119413-54-6 )

Catalog No.:	CL2197
CAS No.:	119413-54-6
Synonym:	Nogitecan hydrochloride; Hycamtin;
Chemical Name:	4-Ethyl-4,9-dihydroxy-10-[(dimethylamino)methyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride; 9-Dimethylaminomethyl-10-hydroxycamptothecin hydrochloride salt; Hycamptamine
Molecular Formula:	C₂₃H₂₃N₃O₅ . HCl
Molecular Weight:	457.91

Technical Data:

Appearance:	Yellow colored powder
Solubility:	Soluble in water
Purity:	>99%
Storage:	at +4℃
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Topotecan hydrochloride :

Size	Price	Stock
100 mg	USD 166	In stock
500 mg	USD 266	In stock
1 g	USD 388	In stock

Biological Activity:

Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin. Used in chemotherapy of several different cancers.

References:

Hendricks CB, Rowinsky EK, Grochow LB, Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue. Cancer Res. 1992 Apr 15;52(8):2268-78.

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