ICONHome   ICONContact us   ICONAdd Favorites
Biochemtek
Search Product
Live Chat E-mail
Pharmacology
ICON Inhibitors
ICON Receptors
ICON Hedgehog Signaling Pathway
ICON Stem Cells & Wnt
ICON Signal Transduction
 　 More +
Research Area
ICON Cancer
ICON Antivirus
ICON Cardiovascular System
ICON Endocrinology
ICON Neuroscience
 　 More +
Product Type
ICON Natural Products
ICON Peptides
ICON Prostaglandins
ICON Vitamin D series compounds
ICON Toxins
 　 More +
Browse Alphabetically by Name
ALL A B C D E F
G H I J K L M
N O P Q R S T
U V W X Y Z Others
 
ICONCL1645 ZM 447439 (331771-20-1)
 
 
Catalog No.: CL1645
CAS No.: 331771-20-1
Synonym: ZM447439; ZM 447439
Chemical Name:

N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazo linyl]amino]phenyl]benzamide

Molecular Formula:

C29H31N5O4

Molecular Weight: 513.59
 
Technical Data:
Appearance: Yellow powder
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of ZM 447439:

Size

Price

Stock

25 mg 

USD 168

In stock 

50 mg 

USD 278

In stock 

100 mg 

USD 496

In stock 

Contact us for competitive discounts on bulk quantities
 
Biological Activity:

Selective and ATP-competitive inhibitor of Aurora B kinase in vitro, with IC50 values to be 50, 250 and 1000 nM for Aurora B, C and A kinases respectively

 
References:
1. Ditchfield C, et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol. 2003 Apr 28;161(2):267-80.
2. Georgieva I, et al. ZM447439, a novel promising aurora kinase inhibitor, provokes antiproliferative and proapoptotic effects alone and in combination with bio- and chemotherapeutic agents in gastroenteropancreatic neuroendocrine tumor cell lines. Neuroendocrinology. 2010;91(2):121-30.
 
View Related Products by Target:
Docetaxel Anhydrous
Decitabine(NSC127716)
Topotecan hydrochloride
Leucovorin calcium(Calcium folinate)
XAV-939(NVP-XAV939)
Roscovitine(CYC202)
SN-38(7-Ethyl-10-hydroxycamptothecin)
CPT-11(Irinotecan hydrochloride)
Carboplatin
Cisplatin(CDDP)
Barasertib-HQPA(AZD1152-HQPA)
Romidepsin(FK228)
 
 

Keywords: Buy ZM 447439 | ZM 447439 Supplier | Purchase ZM 447439 | ZM 447439 Cost | ZM 447439  Manufacturer | Order ZM 447439 | ZM 447439 Distributor | ZM 447439 Structure, Chembest

Buy 331771-20-1| 331771-20-1 Supplier | Purchase 331771-20-1 | 331771-20-1 Cost | 331771-20-1 Manufacturer | Order 331771-20-1 | 331771-20-1 Distributor | 331771-20-1 Structure, Chembest  
Products are for research use only. Not for human use. We do not sell to patients.
Copyright © 2010-2024 Chembest Research Laboratories. All Rights Reserved
E-mail:sales@biochembest.com