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ICONC14119 Romidepsin(FK228) (128517-07-7)
 
 
Catalog No.: C14119
CAS No.: 128517-07-7
Synonym: Depsipeptide,FK228,NSC-630176,FR 901228,Istodax
Chemical Name:

(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone

Molecular Formula:

C24H36N4O6S2

Molecular Weight: 540.70
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Romidepsin(FK228):

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Romidepsin is a novel agent in a new class of anti-cancer drugs, known as histone deacetylase inhibitors or  HDACi's. Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide.

 
References:

1. Karen M. VanderMolen, William McCulloch, Cedric J. Pearce, et al. Romidepsin (Istodax?, NSC 630176, FR901228, FK228, Depsipeptide): A Natural Product Recently Approved for Cutaneous T-cell Lymphoma . J Antibiot (Tokyo). 2011 August; 64(8): 525-531.

2. CE Tiffon, JE Adams, L van der Fits , et al. The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells .Br J Pharmacol. 2011 April; 162(7): 1590-1602.

 
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