Buy Dovitinib lactate hydrate ( TKI258 lactate hydrate; CHIR-258 lactate hydrate)|915769-50-5|Protein-tyrosine kinase|from supplier chembestbuy.com|Research only

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CL2407 Dovitinib lactate hydrate ( TKI258 lactate hydrate; CHIR-258 lactate hydrate) (915769-50-5)

Catalog No.:	CL2407
CAS No.:	915769-50-5
Synonym:	TKI258 lactate hydrate; CHIR-258 lactate hydrate
Chemical Name:	4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate
Molecular Formula:	C₂₁H₂₁FN₆O^.C₃H₆O₃^.H₂O
Molecular Weight:	500.53

Technical Data:

Appearance:	Light yellow to yellow powder
Solubility:	Soluble in DMSO
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Dovitinib lactate hydrate ( TKI258 lactate hydrate; CHIR-258 lactate hydrate):

Size	Price	Stock
25 mg	USD 176	In stock
50 mg	USD 288	In stock
100 mg	USD 488	In stock

Biological Activity:

Dovitinib lactate is the orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.

References:

1. Trudel S, et al. Blood. 2005, 105(7), 2941-2948.

2. Huynh H, et al. J Hepatol. 2012, 56(3), 595-601.

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