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C13332 Atazanavir sulphate (229975-97-7)

Catalog No.:	C13332
CAS No.:	229975-97-7
Synonym:	BMS-232632-05
Chemical Name:	Methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-[(4-pyridin-2-ylphenyl)methyl]amino]-1-phenylbutan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamate sulfate
Molecular Formula:	C₃₈H₅₂N₆O₇^.H₂SO₄
Molecular Weight:	802.93

Technical Data:

Appearance:
Solubility:	Soluble in Water
Purity:	>98%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Atazanavir sulphate:

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

Atazanavir sulfate (BMS-232632-05) is the sulfate salt form of atazanavir, a potent protease inhibitor (IP) for the treatment of human immunodeficiency virus 1 (HIV-1) infection, which prevents the formation of mature HIV virions through the selective inhibition of the virus-specific processing of viral gag and gag-pol polyproteins in infected cells. Although it shows strong anti-HIV-1 activity with MIC₅₀ ranging from 2 to 5 nM, atazanavir has lower antiviral activity against HIV-2 isolates. Atazanavir, which is metabolized by the hepatic cytochrome P450 (CYP) system resulting in two main inactive metabolites, is also an inhibitor of CYP3A4 isoenzyme and P-glycoprotein ATP-dependent efflux pump.

References:

Robin Wood. Atazanavir: its role in HIV treatment. Expert Rev Snti Infect Ther 2008; 6(6): 785-796

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