Buy AZD6244 (Selumetinib)|606143-52-6|Inhibitors|from supplier chembestbuy.com|Research only

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C14159 AZD6244 (Selumetinib) (606143-52-6)

Catalog No.:	C14159
CAS No.:	606143-52-6
Synonym:	AZD6244
Chemical Name:	5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
Molecular Formula:	C₁₇H₁₅BrClFN₄O₃
Molecular Weight:	457.68

Technical Data:

Appearance:
Solubility:	Soluble in DMSO and Ethanol
Purity:
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of AZD6244 (Selumetinib):

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

Selumetinib (AZD6244) is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Phase 3.

References:

1. Huynh H, et al, Mol Cancer Therapy, 2007, 6 (1), 138-146

2. Garon EB, et al, Mol Cancer Thera, 2010, 9 (7), 1985-1994.

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