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C13269 ALK5 Inhibitor(SJN 2511) (446859-33-2)

Catalog No.:	C13269
CAS No.:	446859-33-2
Synonym:	RepSox;E-616452;SJN 2511
Chemical Name:	2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
Molecular Formula:	C₁₇H₁₃N₅
Molecular Weight:	287.32

Technical Data:

Appearance:	White solid
Solubility:	Soluble in DMSO or methanol
Purity:	>99%
Storage:	Store at -20°C (desiccating conditions).
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of ALK5 Inhibitor(SJN 2511):

Size	Price	Stock
50mg	USD320	In Stock
100mg	USD600	In Stock
500mg	Get quote

Biological Activity:

Selective TGF-β type 1 receptor and ALK5 autophosphorylation inhibitor (IC₅₀ = 4 nM for ALK5). Selective for ALK5 over a range of other kinases, including p38 MAPK, JNK1 and GSK3. Replaces Sox2 for reprogramming iPSCs. Active in vitroand in vivo. Cell-permeable.

References:

1. Gellibert F, et al. J Med Chem, 2004, 47(18), 4494-4506.

2. Ichida JK, et al. Cell Stem Cell, 2009, 5(5), 491-503.

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