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Pharmacology

Inhibitors

Receptors

Hedgehog Signaling Pathway

Research Area

Cardiovascular System

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Vitamin D series compounds

Toxins

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C16234 Go 6983 (Goe 6983) (133053-19-7)

Catalog No.:

C16234

CAS No.:

133053-19-7

Synonym:

Goe 6983;Go6983

Chemical Name:

3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide

Molecular Formula:

C26H26N4O3

C₂₆H₂₆N₄O₃

Molecular Weight:

442.51

Technical Data:

Appearance:
Solubility:	Soluble in DMSO
Purity:	>98%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Go 6983 (Goe 6983):

Size	Price	Stock
10mg	USD	In Stock
25mg	USD	In Stock
50mg	USD	In Stock

Biological Activity:

Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.

References:

1. Gschwendt M, et al. FEBS Lett, 1996, 392(2), 77-80.

2. Peterman EE, et al. J Cardiovasc Pharmacol, 2004, 43(5), 645-656.

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