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CL1896 Vandetanib (443913-73-3)

Catalog No.:	CL1896
CAS No.:	443913-73-3
Synonym:	AZD6474 \| ZD6474 \| Zactima \| ZD-6474 \| AZD-6474 \| Caprelsa;4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline
Chemical Name:	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Molecular Formula:	C₂₂H₂₄BrFN₄O₂
Molecular Weight:	475.35

Technical Data:

Appearance:	White powder
Solubility:	Soluble in DMSO
Purity:	HPLC>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Vandetanib :

Size	Price	Stock
100mg	USD86	In Stock
500mg	USD260	In Stock
1g	USD450	In Stock

Biological Activity:

An orally bioavailable tyrosine kinase inhibitor (TKI), targeting VEGFR and EGFR; a potential medication for non-small-cell lung cancer.

References:

1. RS Herbst et al. Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. Expert Opin. Investig. Drugs. 2007, 16, 239-249.

2. SR Wedge et al. ZD6474 Inhibits Vascular Endothelial Growth Factor Signaling, Angiogenesis, and Tumor Growth following Oral Administration. Cancer Res. 2002, 62, 4645-4655.

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