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CL2170 Vorinostat(SAHA) (149647-78-9)

Catalog No.:	CL2170
CAS No.:	149647-78-9
Synonym:	Suberoylanilide hydroxamic acid (SAHA);Zolinza
Chemical Name:	Suberanilohydroxamic acid; N-Hyrdroxy-N'-phenyloctanediamide
Molecular Formula:	C₁₄H₂₀N₂O₃
Molecular Weight:	264.32

Technical Data:

Appearance:	White to off-white crystal powder
Solubility:	Soluble in DMSO and Methanol
Purity:	HPLC>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Vorinostat(SAHA):

Size	Price	Stock
1g	USD110	In Stock
2g	USD200	In Stock
5g	USD450	In Stock
10g	USD800	In Stock
25g	USD1500	In Stock

Biological Activity:

Suberoylanilide Hydroxamic Acid (SAHA) is a potent HDAC (histone deacetylase) inhibitor that has been shown to inhibit proliferation and cause cell cycle arrest at G₁. Experiments suggest that SAHA also causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. Treatment of cells with SAHA also decreases the expression of anti-apoptosis proteins Bcl-xL and survivin.

References:

1. Mydlo, J.H., et al. 1988. Prostate. 12: 343-355. PMID: 3393496
2. Munster, P.N., et al. 2001. Cancer Res. 61: 8492-8497. PMID: 11731433
3. Sun, P.C., et al. 2010. J. Biomed. Sci. 17: 76. PMID: 20846458

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