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HL1005 Genipin (6902-77-8)

Catalog No.:	HL1005
CAS No.:	6902-77-8
Synonym:	(+)-Genipin;Methyl (1S,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
Chemical Name:	1,4a,5,7a-Tetrahydro-1-hydroxy-7-(hydroxymethyl)-cyclopenta(c)pyran-4-carboxylic acid methyl ester
Molecular Formula:	C₁₁H₁₄O₅
Molecular Weight:	226.2

Technical Data:

Appearance:	White needle crystals
Solubility:	Soluble in DMSO, methanol, acetone and ethyl acetate, insoluble in water
Purity:	>99%
Storage:	at -20℃
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Genipin:

Size	Price	Stock
50mg	USD 220	In stock
100mg	USD 350	In stock

Biological Activity:

Cell permeable inhibitor of uncoupling protein 2 (UCP2). Increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Induces apoptosis. Protein cross-linking agent. Anti-inflammatory and anti-angiogenic

References:

1.Ma C, Nie A, Zhang Z, et al. Genipin stimulates glucose transport in C2C12 myotubes via IRS-1 and calcium- dependent mechanism. J Endocrinol. 2012 Dec 20.
2. Parton LE, Ye CP, Coppari R et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 2007 Sep 13;449(7159):228-32.
3. Zhang CY, Parton LE, Ye CP, et al. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab. 2006 Jun;3(6):417-27.

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