Buy Flavopiridol(Alvocidib)|146426-40-6|Inhibitors|from supplier chembestbuy.com|Research only

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CL1832 Flavopiridol(Alvocidib) (146426-40-6)

Catalog No.:	CL1832
CAS No.:	146426-40-6
Synonym:	L868275;HMR-1275
Chemical Name:	2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
Molecular Formula:	C₂₁H₂₀ClNO₅
Molecular Weight:	401.84

Technical Data:

Appearance:	Light yellow solid
Solubility:	Soluble in DMSO
Purity:	>98%
Storage:	at +4℃
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Flavopiridol(Alvocidib):

Size	Price	Stock
5 mg	USD 56	In stock
10 mg	USD 88	In stock
25 mg	USD 136	In stock
50 mg	USD 216	In stock

Biological Activity:

Potent inhibitor of cyclin-dependent kinases (CDKs). Induces apoptosis in certain tumor cells. Interacts with multidrug resistance protein 1 (MRP1)

References:

1.Senderowicz, Adrian M. Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials Investigational New Drugs (1999), 17(3), 313-320

2. Mahoney E, Lucas DM, Gupta SV, Wagner AJ, Herman SE, Smith LL, Yeh YY, Andritsos L, Jones JA, Flynn JM, Blum KA, Zhang X, Lehman A, Kong H, Gurcan M, Grever MR, Johnson AJ, Byrd JC.ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-73. Epub 2012 Jun 27.

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