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CL2091 Tacrolimus(FK506) (104987-11-3)

Catalog No.:	CL2091
CAS No.:	104987-11-3
Synonym:	Fujimycin,Tsukubaenolide,FK5, Prograf, Protopic,FR-900506,L-679934
Chemical Name:	[3 S -[3 R [ E (1 S ,3 S ,4 S )],4 S ,5 R ,8 S ,9 E ,12 R ,14 R ,15 S ,16 R ,18 S ,19 S ,26a R ]]-5,6,8,11,12, 13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3- [2-(4-hydroxy-3-methoxycyclohexyl) -1-methylethenyl]-14, 16-dimethoxy-4,10,12, 18-tetramethyl-8-(2-propenyl)-15, 19-epoxy-3H-pyrido[2,1- c ][1,4] oxaazacyclotricosine-1,7,20, 21(4H,23H)-tetrone, monohydrate.
Molecular Formula:	C₄₄H₆₉NO₁₂
Molecular Weight:	804.02

Technical Data:

Appearance:	Odorless white powder
Solubility:	Soluble in DMSO
Purity:	>99%
Storage:	at -20°C
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Tacrolimus(FK506):

Size	Price	Stock
200 mg	USD 146	In stock
500 mg	USD 268	In stock
1 g	USD 479	In stock

Biological Activity:

Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK506 binding protein and to inhibit the Ca²⁺-dependent phosphatase and protein phosphatase 2B (PP2B; calcineurin). Activates NF-κB through phosphorylation and degradation of IκBα.

References:

Sawada S, Suzuki G, Kawase Y, Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation. J Immunol. 1987 Sep 15;139(6):1797-803.

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