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Vitamin D series compounds

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CL1067 Cyclosporin H (83602-39-5)

Catalog No.:	CL1067
CAS No.:	83602-39-5
Synonym:	D-Meval-Cyclosporine;Csh-cyclosporin;5-(N-Methyl-D-valine)-cyclosporin A
Chemical Name:	Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
Molecular Formula:	C₆₂H₁₁₁N₁₁O₁₂
Molecular Weight:	1202.63

Technical Data:

Appearance:	White crystal Powder
Solubility:	Soluble in DMSO and in ethanol
Purity:	>95%
Storage:	at room temperature
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Cyclosporin H:

Size	Price	Stock
1 mg	USD 178	In stock
5 mg	USD 466	In stock

Biological Activity:

Immunologically inactive. Does not bind to immunophilin. Potent inhibitor of tumor promoting phorbol ester TPA/PMA in mouse skin in vivo. Potent inhibitor of Ca²⁺/calmodulin dependent EF-2 phosphorylation in vitro. Potent and selective antagonist of formyl peptide receptor. Inhibits formyl peptide-induced superoxide formation.

References:

Wenzel-Seifert K & Seifert R Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. J Immunol 150:4591-9 (1993).

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