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CL1637 Axitinib(AG 013736) (319460-85-0)

Catalog No.:	CL1637
CAS No.:	319460-85-0
Synonym:	AG-013736
Chemical Name:	N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
Molecular Formula:	C₂₂H₁₈N₄OS
Molecular Weight:	386.47

Technical Data:

Appearance:	Yellowish to off-white crystalline powder
Solubility:	Soluble in DMSO
Purity:	>99%
Storage:	at +4°C
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Axitinib(AG 013736):

Size	Price	Stock
500 mg	USD 226	In stock
1 g	USD 346	In stock
5 g	USD 768	In stock

Biological Activity:

A tyrosine kinase inhibitor (TKI), targeting VEGFR/PDGFR/c-KIT; orally bioavailable drug exerting an anti-angiogenic effect.

References:

1.Kelly RJ & Rixe O Axitinib--a selective inhibitor of the vascular endothelial growth factor (VEGF) receptor. Target Oncol 4:297-305 (2009).

2.Hu-Lowe DD et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res14:7272-83 (2008).

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