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Cardiovascular System

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Vitamin D series compounds

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CL2143 KU 0063794 (938440-64-3)

Catalog No.:	CL2143
CAS No.:	938440-64-3
Synonym:	KU-63794
Chemical Name:	rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morp holinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzeneme thanol
Molecular Formula:	C₂₅H₃₁N₅O₄
Molecular Weight:	465.54

Technical Data:

Appearance:	Light yellow to yellow powder
Solubility:	Soluble in DMSO
Purity:	>98%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of KU 0063794:

Size	Price	Stock
25 mg	USD 236	In stock
50 mg	USD 366	In stock
100 mg	USD 566	In stock

Biological Activity:

Potent and selective mTOR inhibitor, with IC50 values to be about 10 nM for mTORC1 and mTORC2.

References:

Garcia-Martinez et al Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem.J. (2009)421 29.

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