Buy GDC-0449(Vismodegib)|879085-55-9|Hedgehog Signaling Pathway|from supplier chembestbuy.com|Research only

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Pharmacology

Inhibitors

Receptors

Hedgehog Signaling Pathway

Research Area

Cardiovascular System

Product Type

Vitamin D series compounds

Toxins

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CL1037 GDC-0449(Vismodegib) (879085-55-9)

Catalog No.:	CL1037
CAS No.:	879085-55-9
Synonym:	RG-3616,Vismodegib,HhAntag691
Chemical Name:	2-Chloro-N-(4-chloro-3-pyridin-2-yl-phenyl)-4-methanesulfonyl-benzamide
Molecular Formula:	C₁₉H₁₄Cl₂N₂O₃S
Molecular Weight:	421.3

Technical Data:

Appearance:
Solubility:	Soluble in DMSO and Methanol
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of GDC-0449(Vismodegib):

Size	Price	Stock
100 mg	USD 166	In stock
200 mg	USD 266	In stock
500 mg	USD 466	In stock

Biological Activity:

The first-in-class inhibitor of Hedgehog (Hh) signaling pathway; more specifically, an orally bioavailable and potent inhibitor of smoothened homologue (SMO); an investigational anti-cancer drug for Medulloblastoma, advanced basal cell skin cancer etc.

References:

Scales SJ, et al. Trends Pharmacol Sci. 2009, 30(6), 303-312.

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