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CL1078 Valspodar(PSC-833) (121584-18-7)

Catalog No.:	CL1078
CAS No.:	121584-18-7
Synonym:	SDZ-PSC-833,Amdray;PSC 833;PSC-833;PSC833;Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]
Chemical Name:	6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A;6-[[R-(E)]-6,7-Didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid]-7-L-valinecyclosporin A; 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3- oxo-6-octenoic Acid]ccyclosporin D
Molecular Formula:	C₆₃H₁₁₁N₁₁O₁₂
Molecular Weight:	1214.62

Technical Data:

Appearance:	White solid
Solubility:	Soluble in DMSO,Chloroform and Methanol
Purity:	>98%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Valspodar(PSC-833):

Size	Price	Stock
1 mg	USD 386	In stock
2 mg	USD 516	In stock
5 mg	USD 906	In stock

Biological Activity:

P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A.

References:

1. Tai HL. Technology evaluation: Valspodar, Novartis AG. Curr Opin Mol Ther. 2000 Aug;2(4):459-67.

2. Fei Shen, Barbara J. Bailey, Shaoyou Chu, et al. Dynamic Assessment of Mitoxantrone Resistance and Modulation of Multidrug Resistance by Valspodar (PSC833) in Multidrug Resistance Human Cancer Cells. JPET August 2009,330 (2): 423-429

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