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Biological Activity:
Second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean IC₅₀ =0.46 nM and IC₉₀ =1~10 nM to HIV isolates (n=52)
References:
Maltêz, Fernandoa; Doroana, Manuelab; Branco, Teresac et al. Recent advances in antiretroviral treatment and prevention in HIV-infected patients. Current Opinion in HIV & AIDS. 2011 ,6:S21-S30.