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CL1005 L-Biopterin(NSC 339699) (22150-76-1)

Catalog No.:	CL1005
CAS No.:	22150-76-1
Synonym:	6-Biopterin;NSC 339699; L-erythro-Biopterin
Chemical Name:	(1'R,2'S)-Biopterin; 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine
Molecular Formula:	C₉H₁₁N₅O₃
Molecular Weight:	237.09

Technical Data:

Appearance:	pale yellow powder
Solubility:	Soluble in ethanol
Purity:	>98%
Storage:	Store at room temperature
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of L-Biopterin(NSC 339699):

Size	Price	Stock
50 mg	USD 188	In stock
100 mg	USD 288	In stock
250 mg	USD 468	In stock

Biological Activity:

L-Biopterin is the oxidized form of tetrahydro-L-biopterin (BH₄), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH₄ via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC₅₀ = 0.2 µM after 48 hrs). L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.

References:

Weinberg JB et al. Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages.Blood 86:1184-95 (1995).

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