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C13941 NS-398 (123653-11-2)

Catalog No.:	C13941
CAS No.:	123653-11-2
Synonym:	N-[2-(Cyclohexoxy)-4-Nitro-Phenyl]Methanesulfonamide; N-[2-(Cyclohexoxy)-4-Nitrophenyl]Methanesulfonamide; N-(2-Cyclohexyloxy-4-Nitro-Phenyl)Methanesulfonamide
Chemical Name:	N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide
Molecular Formula:	C₁₃H₁₈N₂O₅S
Molecular Weight:	314.4

Technical Data:

Appearance:
Solubility:	Soluble in DMSO
Purity:	>99%
Storage:	Store at room temperature
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of NS-398:

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

Selective cyclooxygenase-2 inhibitor (IC₅₀ values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.

References:

Du Y et al. Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. Oncol Rep 20:605-11 (2008).

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