Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by 

enhancing mucosal defense, scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2.Studies have shown that Rebamipide can fight the 

damaging effects of NSAIDs on the GIT mucosa, and more recently, the small intestine.It has also been used for the treatment of Behçet's disease.

1. Arakawa T  et al. 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications.Dig Dis Sci 50 Suppl 1:S3-S11 (2005).
2. Kohashi M  et al. Effective treatment with oral administration of rebamipide in a mouse model of Sjögren's syndrome. Arthritis Rheum 58:389-400 (2008).