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C14187 Sorafenib(Nexavar,Bay43-9006) (284461-73-0)

Catalog No.:	C14187
CAS No.:	284461-73-0
Synonym:	Nexavar,Bay43-9006,Sorafenib free base
Chemical Name:	4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
Molecular Formula:	C₂₁H₁₆ClF₃N₄O₃
Molecular Weight:	464.83

Technical Data:

Appearance:
Solubility:	Soluble in DMSO
Purity:	99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Sorafenib(Nexavar,Bay43-9006):

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

Sorafenib is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.

References:

Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109.

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