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ICONC13885 Miglitol (72432-03-2)
 
 
Catalog No.: C13885
CAS No.: 72432-03-2
Synonym: Glyset; Seibule; Diastabol; BAY1099; BAY-m1099
Chemical Name:
1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
Molecular Formula: C8H17NO5
Molecular Weight: 207.22
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Miglitol:

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Biological Activity:
Inhibitor of α-glucosidase; antihyperglycemic. Suppresses postprandial hyperglycemia in vivo and reduces plasma glucose concentration in normal rats and in several animal models of diabetes. Shown to inhibit the loss of pancreatic β cells in type 2 diabetic rats. Also inhibits apoptosis and mitochondrial overproduction of reactive oxygen species in endothelial cells in vitro.
 
References:

1. Asano N Glycosidase inhibitors: update and perspectives on practical use. Glycobiology 13:93R-104R (2003).

2. Tormo MA  et al. Effect of miglitol administration to non-insulin-dependent diabetic rats. Gen Pharmacol 30:125-9 (1998). 
 
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