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C13939 Nolatrexed dihydrochloride (152946-68-4)

Catalog No.:	C13939
CAS No.:	152946-68-4
Synonym:	2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride; AG 337; Thymitaq
Chemical Name:	3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride
Molecular Formula:	C₁₄H₁₂N₄OS^.2(HCl)
Molecular Weight:	357.26

Technical Data:

Appearance:
Solubility:	Soluble in Water
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Nolatrexed dihydrochloride:

Size	Price	Stock
10mg	USD	In Stock
25mg	USD	In Stock
50mg	USD	In Stock

Biological Activity:

Nolatrexed Dihydrochloride is an antineoplastic, antifolate TS (thymidylate synthase) inhibitor.

References:

1. Webber, S E., et al., 1993. Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones. Journal of medicinal chemistry. 36(6): 733-46. PMID: 8459400
2. Webber, S., et al., 1996. AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer chemotherapy and pharmacology. 37(6): 509-17. PMID: 8612303
3. Dash, A K., et al., 1996. Solid-state characterization of AG337 (Thymitaq), a novel antitumor drug. Journal of pharmaceutical sciences. 85(10): 1123-7. PMID: 8897283

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